Joining of the c-myc gene and a line 1 family member on chromosome 8 in a human primary giant cell carcinoma of the lung.
نویسندگان
چکیده
A rearranged c-myc gene found in a human primary giant cell carcinoma of the lung was analyzed. The rearrangement was found in the region about 6 kilobase pairs upstream of the c-myc gene. The breakpoint was joined to a sequence carrying a Line 1 (L1) family member located on chromosome 8. This in vivo rearrangement of the c-myc gene specific to tumor cells may represent one mechanism of activation of a protooncogene during tumorigenesis or tumor progression in human cancer.
منابع مشابه
Joining of the c-myc Gene and a Line 1 Family Member on Chromosome 8 in a Human Primary Giant Cell Carcinoma of the Lung1
A rearranged i--wi.ccgene found in a human primary giant cell carci noma of the lung was analyzed. The rearrangement was found in the region about 6 kilobase pairs upstream of the r-m.ccgene. The breakpoint was joined to a sequence carrying a Line 1 (LI) family member located on chromosome 8. This in vivo rearrangement of the c-myc gene specific to tumor cells may represent one mechanism of act...
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عنوان ژورنال:
- Cancer research
دوره 50 11 شماره
صفحات -
تاریخ انتشار 1990